Methods In Pharmacology And Toxicology - Optimization in Drug Discovery In Vitro Methods 2nd Edition

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Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates.
  • Series: Methods in Pharmacology and Toxicology (Book 18)
  • Hardcover: 597 pages
  • Publisher: Humana Press; 2nd ed. 2014 edition (November 9, 2013)
  • Language: English
  • ISBN-10: 1627037411
  • ISBN-13: 978-1627037419
  • Product Dimensions: 7.2 x 1.5 x 10.1 inches
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