Methods In Pharmacology And Toxicology - Drug Metabolism and Transport Molecular Methods

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A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.
  • Series: Methods in Pharmacology and Toxicology
  • Hardcover: 388 pages
  • Publisher: Humana Press; 2005 edition (September 24, 2004)
  • Language: English
  • ISBN-10: 1588293246
  • ISBN-13: 978-1588293244
  • Product Dimensions: 6.1 x 0.9 x 9.2 inches
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